A Phase II Prospective, Single Blinded, Randomized Trial of Hemopatch Compared to Standard Techniques to Achieve Air Leak Control After Complex Thoracic Surgical Procedures

Inclusion Criteria: * Age ≥18 years * High risk of prolonged air leak due to at least one of the following reasons: * Preoperative FEV1\<80% * DLco \< 80% * LVRS (lung volume reduction surgery o pneumoplastica riduttiva) * Anticipation of intraoperative adhesions (ie, redo surgery) * Previous induction chemotherapy for locally advanced NSCLC * Chronic steroid use * Pleural mesothelioma * Candidate to one of the following major thoracic surgical intervention: * Decortication * Reintervention on the same side of the previous intervention * Segmentectomy * Lobectomy with incomplete fissures on CT scan * Written informed consent. Exclusion Criteria: * Pregnancy or breast-feeding * Evidence of confusion or disorientation, or history of major psychiatric illness that may impair the patient's understanding of the Informed Consent Form or their ability to comply with study requirements * Any unstable systemic disease (including active infections, any significant hepatic, renal or cardiovascular disease), metabolic dysfunction, physical examination finding, or clinical laboratory finding that contraindicates or prevents or the execution of surgery * Known hypersensitivity to bovine proteins or brilliant blue (FD\&C Blue No.1)