Phototherapy in Persons With Multiple Sclerosis

University of Illinois at Urbana-Champaign20 enrolled

Overview

The current study examines the effect of phototherapy equipped with Narrow Band UVB lamps on vitamin D production in persons with MS.

Participants will be exposed to phototherapy according to the 2014 Guidelines issued by the American Academy of Dermatology 3 days per week over an 8-week period.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Multiple Sclerosis

Interventions

PhototherapyDEVICE

Participants will be exposed to phototherapy according to the 2014 Guidelines issued by the American Academy of Dermatology 3 days per week over an 8-week period.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 64 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Female with multiple sclerosis Exclusion Criteria: * Inability to stand still in a stabilized fashion without risk of falling for up to 6 minutes * Known medical history of calcium disorder or knowledge of high calcium levels * Known medical history of hyper-parathyroidism * Current supplementation with oral vitamin D * Known allergy to vitamin D * History of cancer of any type including but not limited to skin cancer * Obesity defined as BMI \> 30 * Known history of fat malabsorption conditions (i.e., steatorrhea) * Current use of anti-epileptic medication * Current use of glucocorticoids * Fitzpatrick skin types I and VI using the Fitzpatrick skin type analysis * Recent use of tanning facilities

Locations (1)

Exercise Neuroscience Research Laboratory

Urbana, Illinois, United States

Outcomes

Primary Outcomes

Change from Baseline in Serum Vitamin D at 4 and 8 weeks

Venous blood will be collected to quantify levels of circulating Vitamin D.

Time frame: 0, 4, and 8 weeks

Secondary Outcomes

Change from Baseline in Walking Speed at 4 and 8 weeks

Participants will walking for 25-feet as fast, but safely, as possible on an instrumented gait mat for measuring gait speed.

Time frame: 0, 4, and 8 weeks

Change from Baseline in Cognitive Function at 4 and 8 weeks

Participants will complete neuropsychological assessments of processing speed and learning and memory.

Time frame: 0, 4, and 8 weeks

Change from Baseline in Mood State at 4 and 8 weeks

Participants will complete a 30-item self-report measure of overall mood.

Time frame: 0, 4, and 8 weeks

Data from ClinicalTrials.gov

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