A Study of Atezolizumab in Combination With Carboplatin Plus (+) Paclitaxel With or Without Bevacizumab Compared With Carboplatin+Paclitaxel+Bevacizumab in Participants With Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

PFS, as Determined by the Independent Review Facility (IRF) in Arm B Versus Arm C in Teff-High-WT Population and ITT-WT Population

PFS, as determined by the independent review facility (IRF) Using RECIST v1.1 in Arm B versus Arm C in the T-effector (Teff)-high wild type (WT) population and the intent-to-treat (ITT)-WT population.

Time frame: Baseline until disease progression or death, whichever occurs first (up to approximately 29 months)

PFS, as Determined by the Investigator in Arm B Versus Arm C in Teff High Population and ITT Population

PFS, as determined by the investigator according to RECIST v1.1, in Arm B versus C in the Teff high population and ITT population.

Time frame: Baseline until disease progression or death, whichever occurs first (up to approximately 29 months)

PFS, as Determined by the Investigator in Arm A Versus Arm B in Teff High-WT Population and ITT-WT Population

PFS, as determined by the investigator according to RECIST v1.1, in Arm A versus B in the Teff high-WT population and ITT-WT population.

Time frame: Baseline until disease progression or death, whichever occurs first (up to approximately 29 months)

PFS, as Determined by the Investigator in Arm B Versus Arm C by PD-L1 Subgroup

PFS as Determined by the Investigator according to RECIST v1.1, in Arm B Versus Arm C by PD-L1 Subgroup: TC2/3 or 1C2/3 and TC1/2/3 or IC1/2/3 (ITT-WT Population)

Time frame: Baseline until disease progression or death, whichever occurs first (up to approximately 29 months)

OS in Arm B Versus Arm C by PD-L1 Subgroup

OS in Arm B Versus Arm C by PD-L1 Subgroup: TC2/3 or 1C2/3 and TC1/2/3 or IC1/2/3 (ITT-WT Population)

Time frame: Baseline until death (up to approximately 34 months)

OS in Arm A Versus Arm C by PD-L1 Subgroup

OS in Arm A Versus Arm C by PD-L1 Subgroup: TC2/3 or 1C2/3 and TC1/2/3 or IC1/2/3 (ITT-WT Population)

Time frame: Baseline until death (up approximately 53 months)

OS in Arm B Versus Arm C in Teff High-WT Population, Teff High Population, and ITT Population

Time frame: Baseline until death (up to approximately 34 months)

OS in Arm A Versus Arm C in Teff High-WT Population, Teff High Population, and ITT Population

Time frame: Baseline until death (up approximately 53 months)

OS in Arm A Versus Arm B in Teff High-WT Population and ITT-WT Population

Time frame: Baseline until death (up approximately 53 months)

Duration of Response (DOR), as Determined By Investigator in Arm B Versus Arm C

DOR, as determined by investigator according to RECIST v1.1 in Arm B versus Arm C in the Teff high-WT population and the ITT-WT population.

Time frame: Baseline until disease progression or death, whichever occurs first (up to approximately 29 months)

Percentage of Participants With an Objective Response (OR) (Complete Response [CR] or Partial Response [PR]) as Determined by the Investigator in the Teff-High-WT Population and ITT-WT Population

Percentage of Participants With an Objective Response (OR) (Complete Response \[CR\] or Partial Response \[PR\]) as Determined by the Investigator using RECIST v1.1 in the Teff-High-WT population and ITT-WT population.

Time frame: Baseline until disease progression or death, whichever occurs first (up to approximately 29 months)

OS Rates at Years 1 and 2 in Arm B Versus Arm C

OS at 1- and 2-year landmark timepoints in Teff-high WT population and ITT-WT population.

Time frame: Baseline to 2 years or death, whichever occurs first.

OS Rates at Years 1 and 2 in Arm A Versus Arm C

OS at 1- and 2-year landmark timepoints in Teff-high WT population and ITT-WT population.

Time frame: Baseline to 2 years or death, whichever occurs first.

Time to Deterioration (TTD) in Patient-Reported Lung Cancer Symptoms Determined by European Organization for Research and Treatment of Cancer (EORTC) Quality-of-Life Questionnaire-Core 30 (QLQ-C30) Score

EORTC QLQ-C30 is a validated \& reliable self-report measure (Aaronson et al.1993;Fitzsimmons et al.1999) that consists of 30 questions that assess 5 aspects of patient functioning (physical,emotional,role, cognitive,and social), 3 symptom scales (fatigue,nausea \& vomiting, pain),global health/quality of life,and six single items (dyspnea,insomnia, appetite loss,constipation,diarrhea, and financial difficulties). EORTC QLQ-C30 is scored according to the EORTC scoring manual (Fayers et al. 2001). All EORTC scales and single-item measures are linearly transformed so that each score has a range of 0-100. A high score for a functional/global health status scale represents a high or healthy level of functioning/HRQoL (Health-Related Quality of Life);however a high score for a symptom scale or item represents a high level of symptomatology or problems. A ≥10-point change in the symptoms subscale score is perceived by patients as clinically significant (Osoba et al.1998).

Time frame: Baseline up to approximately 29 months

TTD in Patient-Reported Lung Cancer Symptoms as Determined by EORTC Quality-of-Life Questionnaire-Core Lung Cancer Module 13 (QLQ-LC13) Score

QLQ-LC13 Quality-of-Life Questionnaire Lung Cancer Module incorporates one multiple-item scale to assess dyspnea and a series of single items assessing pain, coughing, sore mouth, dysphagia, peripheral neuropathy, alopecia, and hemoptysis. The EORTC QLQ-LC13 is scored according to the EORTC scoring manual (Fayers et al. 2001). All EORTC scales and single-item measures are linearly transformed so that each score has a range of 0-100. A high score for a functional/global health status scale represents a high or healthy level of functioning/HRQoL (Health-Related Quality of Life); however, a high score for a symptom scale or item represents a high level of symptomatology or problems. A ≥10-point change in the symptoms subscale score is perceived by patients as clinically significant (Osoba et al. 1998).

Time frame: Baseline up to approximately 29 months

Change From Baseline in Patient-Reported Lung Cancer Symptoms Score Using the Symptoms in Lung Cancer (SILC) Scale

The SILC (Symptoms in Lung Cancer) scale was used to assess patient-reported severity of lung cancer symptoms (chest pain, dyspnea, and cough). The SILC scale is a 9-item content validated self-report measure of lung cancer symptoms. It measures severity of cough, dyspnea, and chest pain with a symptom severity score. The SILC questionnaire comprises three individual symptoms (dyspnea, cough, chest pain) and are scored at the individual symptom level, thus have a dyspnea score, chest pain score, and cough score. Each individual symptom score is calculated as the average of responses for the symptom items \[e.g. Chest Pain Score=mean (item 1; item 2)\]. An increase in score is suggestive of a worsening in symptomology (i.e. frequency or severity). A score change of ≥0.3 points for the dyspnea and cough symptom scores is considered to be clinically significant; whereas a score change of ≥0.5 points for the chest pain score is considered to be clinically significant.

Time frame: Baseline up to approximately 29 months

Percentage of Participants With Adverse Events

Percentage of participants with at least one adverse event.

Time frame: Baseline up to data cutoff date 7 December 2020 (up to approximately 68 months)

Percentage of Participants With Anti-Therapeutic Antibodies (ATAs) to Atezolizumab

Time frame: Baseline up to approximately 29 months

Maximum Observed Serum Concentration (Cmax) of Atezolizumab in Arm A and Arm B

The predose samples will be collected on the same day of treatment administration. The infusion duration of atezolizumab will be of 30-60 minutes.

Time frame: Day 1 of Cycle 1 and 3 (Cycle length=21 days)

Minimum Observed Serum Concentration (Cmin) of Atezolizumab Prior to Infusion in Arm A and Arm B

Time frame: Day 21 of Cycles 1, 2 3, and 7 (Cycle length=21 days)

Plasma Concentrations for Carboplatin in Arm A, Arm B, and Arm C

Time frame: Predose (same day of treatment administration), 5-10 minutes before end of carboplatin infusion, 1 h after carboplatin infusion (infusion duration=15 to 30 minutes) on D1 of Cy1,3 (Cycle length=21 days)

Plasma Concentrations for Paclitaxel in Arm A, Arm B, and Arm C

Time frame: Predose (same day of treatment administration), 5-10 minutes before end of paclitaxel infusion, 1 h after paclitaxel infusion (infusion duration=3 h) on D1 of Cy1,3 (Cycle length=21 days)

Cmax of Bevacizumab in Arm B and Arm C

Time frame: Cycle 1 Day 1 and Cycle 3 Day 1 (Cycle length=21 days)

Cmin of Bevacizumab in Arm B and Arm C

Time frame: Cycle 1 Day 1 and Cycle 2 Day 21 (Cycle length=21 days)