The Effect of Locally Delivered Ciclosporin as an Adjunct to Healing After Treatment of Periodontal Pockets

Inclusion Criteria: * Patients in good general health * 2 pairs of contralateral interproximal periodontal sites with probing depths of ≥7mm in single-rooted teeth not associated with furcations or root furrows.The test sites should have a distance of at least two teeth to the control sites. * Teeth selected should have a vital pulp as determined by thermal or electric stimulation Exclusion Criteria: * Patients already included in other clinical trials involving therapeutic intervention (either medical or dental) * Periodontal treatment during the last 6 months * Antibiotic treatment 6 months prior to the start of the trial * Antibiotic prophylaxis required for dental treatment * Patients with acute infectious lesions in the areas of intended treatment * Regular anti-inflammatory medication * Known history of ciclosporin allergy * Ongoing medication that may affect the clinical features of periodontitis * Patients who are smokers * Patients that are immuno-compromized or on immunosuppressive medication * Patients who are pregnant or lactating