The purpose of this prospective, non-interventional clinical study is to assess the clinical validity of a number of markers (including Heparin Binding Protein (HBP), Procalcitonin (PCT), C-reactive protein (CRP), White cell count (WCC) and lactate) for indicating the presence of organ dysfunction, or outcome, of patients with organ dysfunctions following emergency department admission or hospitalization. Secondary objectives are to identify novel putative biomarkers and to identify risk factors for negative long-term effects of acute critical illness The HBP assay is an enzyme-linked immunosorbent assay (ELISA) for the quantitative determination of Heparin Binding Protein in human plasma.
Study Type
OBSERVATIONAL
Enrollment
600
John Boyd
Vancouver, Canada
COMPLETEDHelsingborg
Helsingborg, Sweden
RECRUITINGLund ED
Lund, Sweden
RECRUITINGBern ED
Bern, Switzerland
COMPLETEDinfection-induced organ dysfunction
To evaluate the presence or development of infection-induced organ dysfunction within a 72 hour time period from enrolment at the Emergency Department.
Time frame: 72 hours
To compare the specificity, sensitivity and accuracy of HBP against other biochemical markers
Time frame: 72 hours
To investigate the specificity, sensitivity and accuracy in biochemical markers to predict mortality, ICU-care, days in hospital and the persistence of organ dysfunction.
Time frame: 90 days
To investigate and identify risk factors for a negative long-term (5-10 year) outcome.
Time frame: 10 years
• Organ dysfunction 24-36 and 72 hours after arriving at the hospital
Time frame: 72 hrs
• Primary diagnosis infection (y/n)
Time frame: 72 hrs
• number of days on ward and ICU
Time frame: 90 days
• number of days of antibiotics , time to effective antibiotics
Time frame: 72 hrs
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