Penn State TXT2Quit Study

Inclusion Criteria: * Smoke \>4 cigarettes/day for at least 6 months * Age 21+ * Want to quit and ready to try in next 30 days * Willing to quit all forms of tobacco (including e-cigs) * Willing to use Chantix to try to quit * Have a cell phone able to receive text messages * Willing to attend 3 visits and use varenicline for smoking cessation * Plan to live in local area for next 6 months * Read and write in English * Women not pregnant and taking steps to avoid * Able to understand and willing to sign consent Exclusion Criteria: * History of allergic reaction or other adverse event while using varenicline * Used a smoking cessation aid/medicine in past 1 month (including e-cigs) * Currently pregnant or nursing * Does not have a mobile phone that can send and receive text messages or unwilling to receive study texts * Uncontrolled serious mental illness or substance abuse or inpatient treatment for these in the past 6 months * Uses non-cigarette tobacco products and does not plan to quit all tobacco. * Has a history of kidney problems or receives dialysis * Had any thoughts that they would be better off dead or of deliberate self-harm in the prior 4 weeks * Had a heart attack in the past 4 weeks * Mental conditions that would prohibit the participant from completing the protocol