Dose-escalation Phase 1 to Evaluate the Safety and Efficacy of MG1111 in Healthy Adults

Inclusion Criteria: 1. Healthy male and female individuals between 20 and 55 years of age at screening test * In the case of female, individuals must be applicable for one of the following; * In the case of female of childbearing potential, any negative pregnancy test using urine hCG at screening * Menopausal for at least 2 years * Surgical sterilization (status after hysterectomy, bilateral oophorectomy, bilateral tubal ligation or the status using other contraceptive methods) * Monogamous relationship with vasectomized partner prior to screening visit * Individuals who are used acceptable contraceptive methods from 3 month prior to the subject's study entry to 1 month after vaccination (acceptable contraceptive methods; condom, diaphragm or cervical cap) 2. If male who is sexually active with the female "of childbearing potential" , the individuals who agree to use any of the acceptable contraceptive methods during this study period and agree to not donate the sperm until 1 month 3. At screening visits, individuals who are over 55 kg in man, over 50kg in woman and whose ideal body weight is within 20 % ((ideal body weight = (height -100)\*0.9) 4. Individual who has no clinically significant abnormalities in screening test within 28 days prior to vaccination 5. Individuals who were voluntarily signed informed consent form after receiving education about this study and able to comply with the requirements for the study Exclusion Criteria: 1. Individuals who received any other vaccines within 4 weeks prior to the screening visit 2. Individuals who are planning to receive the other vaccines during this study 3. Individuals who had wound, scar, tattoo, dermatological disorders or injection affecting safety evaluation 4. Individuals with alcohol or caffeine abuse or heavy smoker (caffeine : \>5 cups/day, alcohol : 210g/week, smoke : 10 /day) 5. Individuals who received any other investigational product within 90 days prior to vaccination 6. individuals who donated the whole blood within 60 days or apheresis within 30 days prior to vaccinating investigational product 7. Individuals who administered with another prescription medicine, herbal medicine within 14 days or over-the-counter drug or vitamins within 7 days before vaccination 8. Individuals with history or illness affecting immune system (1) individuals with continuously anti-viral therapy within 6 months prior to participating in this study (2) Individuals with leukemia, lymphoma, other malignant neoplasm or hematodyscrasia affecting the bone marrow or lymphatic system (3) Immunodeficient individuals (primary or acquired immunodeficiency states, immunodeficiency, hypogammaglobulinemia, dysgammaglobulinemia) (4) Individuals who are receiving immunosuppressive therapy (5) Individuals who have treated immunoglobulin or blood-derived products within 6 months of enrollment (6) Individuals with a family history of congenital or hereditary immunodeficiency 9. Individuals with any clinically relevant history of other disease or disorder - gastrointestinal, respiratory, renal, hepatic, neurological (Guillain-Barre syndrome), psychiatric or malignant tumor 10. Individuals with any febrile illness or body temperature ≥38℃ before vaccination 11. Individuals known hypersensitivity or allergy to components of investigational product (including gelatin and neomycin) 12. Individuals who are any clinically significant abnormality following the investigator's review of the pre-study physical examination, ECG, and clinical laboratory tests 13. Pregnancy or breastfeeding 14. Any other ineligible condition at the discretion of the investigator that would be ineligible to participate the study