Length of Effect of Extended Release Aspirin on Platelets in Patients With Diabetes and Heart Disease

Inclusion Criteria: * Male or non-lactating, non-pregnant female subjects * A history of Type 2 Diabetes and with history of at least one of the following: Coronary Artery Disease, Peripheral Vascular Disease, or Ischemic Stroke, along with at least 2 CVD risk factors (obese, smoker, ≥ 55 years of age, prior thrombotic event) Exclusion Criteria: * Sensitivity to aspirin or any NSAID (nonsteroidal antiinflammatory drug), * Evidence of uncontrolled or unstable cardio- or cerebrovascular disorder, * Presence of uncontrolled or chronic medical illness, GI disorder or surgery leading to impaired drug absorption, clinically significant abnormal baseline ECG, history of hepatitis, malignancy within the past five years, or HIV, history of alcohol or drug abuse.