Proteomic Analysis in Sera From Patients With Erosive Hand Osteoarthritis

Inclusion Criteria: * Female gender * Less than 70 years old * Diagnosis of hand osteoarthritis according to ACR criteria ACR after exclusion of thumb base osteoarthritis: 1. Hand pain, aching or stiffness most of the days during the preceding month 2. Hard tissue enlargement of at least two of 8 selected joints \* 3. Hard tissue enlargement of at least two distal interphalangeal joint 4. Swelling of fewer than three metacarpophalangeal joint 5. Deformity of at least one of 10 selected joints \* Patients have to fulfil criteria 1, 2 AND 3 + 4 OR 5 \* the 8 selected joints are the second and third distal interphalangeal joint and the second and third proximal interphalangeal of both hands Then confirm by experts' committee * Exclusively symptomatic treatment * For women of child-bearing age, use of an effective contraceptive method * French spoken and read Exclusion Criteria: * Male gender * More than 70 years old * Hemochromatosis * Inflammatory arthritis * Cristal induced arthritis * Active diseases such as infection or cancer * Use of DMARDs * Pregnant or breast-feeding woman