This is a multi-center prospective study. The primary objective of DRONE study is to investigate the change of the size of HIV-1 DNA reservoir in blood from baseline to week 48 (W48) in participants treated by DTG-based regimen. Secondary objectives include: DTG pharmacokinetic and analysis of biomarkers of immune activation from baseline to W48.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
202
Centre hospitalier de Belfort-Montbéliard
Belfort, France
ACTIVE_NOT_RECRUITINGCentre hospitalier de Colmar
Colmar, France
RECRUITINGCentre hospitalier de Mulhouse
Mulhouse, France
RECRUITINGChange from baseline in Proviral HIV-1 DNA at Week 48
Time frame: baseline (Day 0) and Week 48
Dolutegravir pharmacokinetic (dolutegravir pharmacological blood levels)
Time frame: Week 4, Week 24 and Week 48
Quantification of biomarkers of immune activation
CRPus, IL-6, neopterin, D-dimer, CD14s
Time frame: baseline (Day 0), Week 24 and Week 48
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Hôpitaux Universitaire de Strasbourg
Strasbourg, France
RECRUITING