The purpose of this study is to examine the effect of nutritional supplementation during hemodialysis treatment on beat-to-beat hemodynamics and treatment efficiency in a crossover design.
The consumption of food or nutritional supplements during hemodialysis treatment has been shown to improve nutritional status, improve quality of life, and reduce mortality. Despite these observations, allowing patients to eat food during hemodialysis treatment is sometimes restricted in the United States. The reasons for this restrictive policy are multi-factorial, but include concerns related to drops in blood pressure BP or a reduced efficiency of solute removal following eating during HD treatment. An alternative to eating solid food is to provide patients with liquid nutritional supplements. Clinics in the US are more likely to allow the consumption of liquid nutritional supplements, however, little is known about the effect that liquid supplements have on blood pressure or treatment efficiency. Therefore, the investigators plan to examine the effect of nutritional supplementation during hemodialysis treatment on hemodynamics and treatment efficiency in a crossover design.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
20
Patients will be asked to consume a single 8 oz can of Nepro
University of Illinois
Urbana, Illinois, United States
Changes in beat-to-beat systolic blood pressure
Beat-to-beat blood pressure will be monitored throughout the treatment by finger plethysmography
Time frame: Duration of each treatment (approximately four hours), treatments will be one week apart for a total of three weeks
Gastrointestinal symptoms during treatment by a rating scale
A validated version of the Gastrointestinal Symptom Rating Scale will be administered
Time frame: Duration of each treatment (approximately four hours), treatments will be one week apart for a total of three weeks
Treatment efficiency measured by urea removal
Kt/V as determined from blood urea pre- and post-hemodialysis
Time frame: Duration of each treatment (approximately four hours), treatments will be one week apart for a total of three weeks
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