Asthma in the elderly is poorly understood, as most studies have not included this patient group. In a previous study of adults with asthma, choline supplementation had a positive effect on asthma symptoms and allowed to decrease asthma pharmacologic treatment. The present study is a randomized, double-blind, placebo-controlled, cross-over study of choline supplementation. The investigators will study the effect of choline 650 mg taken orally twice daily x 6 weeks versus placebo on asthma symptom scores (Asthma Control Test) and spirometric values (FEV1, FEV1/FVC, FEF25-75%). The investigators will also look at the effect of choline supplementation on peripheral blood eosinophils, serum immunoglobulin E (IgE) and homocysteine levels.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
30
Rohr and Columbo Asthma, Allergy and Immunology Specialists, P.C.
Bryn Mawr, Pennsylvania, United States
Effect of choline supplementation on asthma symptoms measured by the Asthma Control Test
Time frame: six weeks
Effect of choline supplementation on spirometric values (FEV1, FEV1/FVC, FEF25-75%)
Time frame: six weeks
Effect of choline supplementation on peripheral blood eosinophils
Time frame: six weeks
Effect of choline supplementation on serum IgE
Time frame: six weeks
Effect of choline supplementation on serum homocysteine levels
Time frame: six weeks
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