The Effect of Different Macronutrients on Gastrointestinal Hormone Secretion After Gastric Bypass Operation

Kirstine Nyvold Bojsen-Moeller18 enrolled

Overview

The purpose of this study is to determine the type of macronutrient (carbohydrate, lipid or protein) that most potently stimulates the endogen secretion of different gut hormones (primary outcome = Glucagon-Like peptide-1) in gastric bypass operated patients. The study also includes a comparison of the secretion of gut hormones after oral intake of lipid with or without a pancreatic lipase inhibitor.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Bariatric Surgery (Gastric Bypass)Overweight

Interventions

Mealtest: High protein 200 kcal 200 ml liquid meal consumed during 10 minutesOTHER

Mealtest: High fat 200 kcal 200 ml liquid meal consumed during 10 minutesOTHER

Mealtest: High carbohydrate 200 kcal 200 ml liquid meal consumed during 10 minutesOTHER

Eligibility

Sex: ALLMin age: 25 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

RYGB Patients: Inclusion Criteria: * Underwent RYGB surgery more than 18 months earlier, weight stabile (+/- 5 kg during 1 month) Exclusion Criteria: * Inadequate thyroid substitution, undergoing treatment with drugs known to interact with Orlistat (such as cyclosporine, anticoagulating agents, amiodarone, amlodipine and epileptics), where pausing the treatment with these is not an option. Type 1 or 2 diabetes mellitus now or prior to RYGB operation. Serious heart or respiratory illness. Haemoglobin levels below 6,5 mM. Healthy control subjects: Inclusion Criteria: * Have not underwent bariatric surgery. Exclusion Criteria: * Inadequate thyroid substitution, undergoing treatment with drugs known to interact with Orlistat (such as cyclosporine, anticoagulating agents, amiodarone, amlodipine and epileptics), where pausing the treatment with these is not an option. Type 1 or 2 diabetes mellitus now or prior. Serious heart or respiratory illness. Haemoglobin levels below 6,5 mM.

Locations (1)

Endocrinology Research Center, Hvidovre University Hospital

Hvidovre, Copenhagen, Denmark

Outcomes

Primary Outcomes

Within group difference in Glucagon-like Peptide 1 secretion (evaluated by iAUC).

I.e. Comparison of GLP-1 secretion (iAUC) as a result of intake of different macronutrients between a) gastric bypass patients only b) healthy volunteers only.