Effects of Isoflavone Combined With Astaxanthin on Skin Aging

Seoul National University Hospital90 enrolled

Overview

Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the intrinsic aging process, and accounts for the majority of age-associated changes in skin appearance. Reactive oxygen species (ROS) play a key role in UV-induced skin damage and diminish skin matrix protein levels, leading skin aging. Strategies utilizing endogenous skin antioxidants as well as plant-derived or synthetic compounds have been examined. Astaxanthin mainly from marine algae and crustaceans is a kind of carotenoids which were well-known photo-protective agents with strong antioxidant activity. Several studies have revealed that supplementation of astaxanthin effectively protect skin against UV damage through free radicals. In addition, matrix metalloproteinase-1 induced by UV irradiation is an important step toward skin aging. Recently, many studies pointed out that phytoestrogens exhibit agonistic and antagonistic estrogen activities, suppressing activity of MMP-1 in skin. Isoflavone is a kind of phytoestrogen from soybean and mainly act on skin and bones, inhibiting MMP-1 effectively. The present study is designed to take isoflavone combined with astaxanthin to maximize their anti-aging ability and objectively measure the effects of the mixture on facial wrinkles, hydration, and elasticity.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Ageing Photo-aging

Eligibility

Sex: FEMALEMin age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy females aged ≥ 45 years * Facial wrinkle grade 2 to 4 Exclusion Criteria: * received medical or cosmetic treatment that interferes with the general aging process at least 3 months before the study * received any hormone replacement therapy at least 3 months before the study * reported taking functional foods more than 1 month during last 3 months before the study * history of acute or chronic disease such as severe liver or kidney disease * history of allergies against any component of trial foods * any visible skin disease that might be confused with a skin reaction to the test procedure

Outcomes

Primary Outcomes

Change from baseline in skin wrinkles

Facial wrinkles in the crow's feet area measured by Skin Visiometer

Time frame: Twenty-four weeks

Secondary Outcomes

Change from baseline in skin elasticity

Facial elasticity measured by Cutometer

Time frame: Twenty-four weeks

Change from baseline in epidermal hydration

Skin hydration measured by Corneometer

Time frame: Twenty-four weeks

Change from baseline in skin barrier integrity

TEWL measured by Tewameter

Time frame: Tewnty-four weeks

Effects of Isoflavone Combined With Astaxanthin on Skin Aging

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes