Thromboelastogram During Total Knee Replacement

Rambam Health Care Campus30 enrolled

Overview

Verify the changes in coagulation system during total knee replacement surgery with tranexamic acid single bolus infusion.

The study was set to reveal changes in the coagulation and fibrinolytic systems during total knee surgery and especially during tourniquet placement, tourniquet removal and revascularization of ischemic limb, after tranexamic acid single bolus infusion, and at post operative day 1.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Orthopedic Procedures, Tranexamic Acid

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Osteoarthrosis * TKR operation elective * ASA I-III Exclusion Criteria: * TKR due to any reason but osteoarthrosis * known coagulation problems * platelets \< 100,000/DcL * Hb \< 12 g% * past thrombo-embolic event * treatment with aspiring during last week * treatment with NSAID's during last 48 hours * malignancy * known allergy to tranexamic acid * general anesthesia

Outcomes

Primary Outcomes

Change in coagulation status during and after surgery compared to pre-surgery

Time frame: During and after surgery compared to pre-surgery

Change in fibrinolytic activity during and after surgery compared to pre-surgery

Time frame: During and after surgery compared to pre-surgery

Data from ClinicalTrials.gov

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