Phase I Trial to Assess the Safety, Tolerability and Immunogenicity of a Ebola Virus Vaccine

Inclusion Criteria: * Healthy adult male or non-pregnant, non-lactating female, ages 18 to 65 (inclusive) at the time of screening * Have provided written informed consent before screening * Free of clinically significant health problems, as determined by pertinent medical history and clinical examination prior to entry into the study * Available, able, and willing to participate for all study visits and procedures * Males and females who are willing to practice abstinence from sexual intercourse, or are willing to use effective methods of contraception, from at least 30 days prior to vaccination until study end. * If the female partner is NOT of childbearing potential, the couple will only be required to use condoms, without other adjunctive contraception. * For this study, a woman is considered of childbearing potential unless postmenopausal (≥ 1 year without menses) or surgically sterilized (tubal ligation, bilateral oophorectomy, or hysterectomy) * Effective contraception is defined as a contraceptive method with failure rate of less than 1% per year when used consistently and correctly and when applicable, in accordance with the product label, for example: * Male condoms PLUS: Oral contraceptives, either combined or progestogen alone, injectable progestogen,implants of etonogestrel or levonorgestrel, oestrogenic vaginal ring, percutaneous contraceptive patches, intrauterine device or intrauterine system * Be willing to minimize blood and body fluid exposure of others for 7 days after vaccination * Use of effective barrier prophylaxis, such as latex condoms, during penetrative sexual intercourse * Avoiding the sharing of needles, razors, or toothbrushes * Avoiding open-mouth kissing Exclusion Criteria: * History of prior infection with a filovirus or prior participation in a filovirus vaccine trial * History of prior infection with VSV or receipt of a VSV vectored vaccine * Is a healthcare worker who has direct contact with patients * Has a house-hold contact (HHC) who is immunodeficient, HIV-positive, pregnant, has an unstable medical condition, or is under the age of 5 years * Is a childcare worker who has direct contact with children 5 years of age or younger * Directly prepares food in the food industry * History of employment in an industry involved in contact with ruminant animals, veterinary sciences, or other potential exposure to VSV * History of employment or activity which involves potential contact with filoviruses * History of severe local or systemic reactions to any vaccination or a history of severe allergic reactions * Known allergy to the components of the BPSC-1001 vaccine product * Receipt of investigational product up to 30 days prior to enrollment or ongoing participation in another clinical trial involving an investigational product * Receipt of licensed vaccines within 30 days of planned study immunization * Ability to observe possible local reactions at the eligible injections sites (deltoid region) is, in the opinion of the investigator, unacceptably obscured due to a physical condition or permanent body art * Acute or chronic, clinically significant psychiatric, hematologic, pulmonary, cardiovascular, or hepatic or renal functional abnormality as determined by the investigator based on medical history, physical exam, ECG, and/or laboratory screening test * Any baseline laboratory screening tests which is outside of acceptable range as defined in the protocol ALT, AST, creatinine, hemoglobin, platelet count, total white blood cell count, urine protein, urine occult blood, urine glucose * Any serologic evidence of hepatitis B or C infection * Any confirmed or suspected immunosuppressive or immunodeficient condition, including human immunodeficiency virus (HIV) infection, cytotoxic therapy in the previous 5 years, and/or diabetes * Any chronic or active neurologic disorder, including migraines, seizures, and epilepsy, excluding a single febrile seizure as a child * Have an active malignancy or history of metastatic or hematologic malignancy * Suspected or known alcohol and/or illicit drug abuse within the past 5 years * Moderate or severe illness and/or fever greater than 100.4 F within one week prior to vaccination * Pregnant or lactating female, or female who intends to become pregnant during the study period * Administration of immunoglobulins and/or any blood products within the 120 days preceding study entry or planned administration during the study period * History of blood donation within 60 days of enrollment or plans to donate within the study period * Administration of chronic (defined as more than 14 days) immunosuppressants or other immune modifying drugs within 6 months of study entry * For corticosteroids, this will mean prednisone, or equivalent, greater than or equal to 0.5 mg/kg/day * Intranasal and topical steroids are allowed * Unwilling to allow storage and use of blood for future vaccine research * Any other significant finding that in the opinion of the investigator would increase the risk of the individual having an adverse outcome from participating in this study