Radioiodine (I-131) therapy for thyroid disease is known to decrease salivary function in adult patients. The impact of pediatric I-131 exposure on salivary function is unknown. The investigators goals are to answer this question by measuring salivary gland function before and after I-131 administration in children who receive radioiodine therapy at our hospital for thyroid disease.
Radioiodine (I-131) therapy for thyroid disease is known to decrease salivary function in adult patients. The impact of pediatric I-131 exposure on salivary function is unknown. The investigators goals are to answer this question by measuring salivary gland function before and after I-131 administration in children who receive radioiodine therapy at our hospital for thyroid disease. We will use a Modified Shirmer Test to measure saliva production and a questionnaire to evaluation symptoms of xerostomia.
Study Type
OBSERVATIONAL
Enrollment
70
We will determine if prior radioiodine treatment in childhood impacts salivary function or symptoms. Radioiodine treatment will have been determined by the patient's medical condition and care (NOT assigned by this research study).
Boston Children's Hospital
Boston, Massachusetts, United States
Salivary function (MST value)
sterile paper strip is used to measure saliva production (noninvasive testing)
Time frame: 0 to 50 years after radioiodine treatment
Responses to Dry Mouth Questionnaire
Patient questionnaire/survey
Time frame: At time of visit up to 4 months thereafter.
Caries history (number of caries noted in dental records)
Time frame: 1 year before radioiodine administration to 4 months after study visit.
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