Phase II Study of Icotinib With Concurrent Radiotherapy in Elderly Patients With Esophageal Cancer

Inclusion Criteria: 1. Pathologically confirmed esophageal carcinoma 2. Stage I～Iva By EUS and CT/MRI, without contraindication for radical radiotherapy 3. Aged ≥ 70 and \< 85 years, behavioral status evaluation ECOG scores 0-2 4. In 7 days after being screened, subjects should follow the status: WBC ≥ 3.0 x 10\^9/L; ANC ≥ 1.5x 10\^9/L; PLT ≥ 80 x 10\^9/L; Hb ≥ 90 g/L; serum Cr ≤ ULN; serum bilirubin ≤ 1.5 ULN; ALT/AST ≤ 1.5 ULN 5. Subjects should sign for the informed consent 6. Subjects should perform good compliance Exclusion Criteria: 1. Patients who have or are currently undergoing additional chemotherapy, radiation therapy or targeted therapy 2. Complete obstruction of the esophagus, or patients who have the potential to develop perforation 3. Patients with a history of malignancy (except that skin carcinomas or in situ breast cancer, oral cancer and cervical cancer with expected survival ≥2 years 4. Patients who have multiple foci esophageal carcinomas 5. Patients who are/were given any other medicine tests currently/in last 4 weeks 6. Experienced hypersensitiveness with similar medicine or other kinds of bio-medicines 7. Patients who have complications as following: (1) Uncontrolled angina and heart failure, have a history of hospitalization in 3 months; (2) A history of myocardial infarction in the past 6 months; (3) There is a need for antibiotic treatment of acute bacterial or fungal infection; (4) Chronic obstructive pulmonary disease, or other lung disease requiring hospitalization; (5) Drug addiction, alcoholism and AIDS disease or long-term virus carriers; (6) Uncontrollable seizures, or loss of insight because of mental illness.