Efficacy of Intermittent ThetaBurst Stimulation Compared to 10 Hz Stimulation on Dorsolateral Prefrontal Cortex in Treatment Resistant Major Depressive Disorder: a Double-blind Randomized Study

Inclusion Criteria: * Age 18 years to 75 years * Both gender eligible * Volontary and able to give consent * Major depressive episode (MADRS \> 20) single or recurrent * Resistance to at least 2 antidepressants , * Treated by antidepressant at efficient stable posology since more than 6 weeks Exclusion Criteria: * Initiation or modification of antidepressant drug * Neurodegenerative diseas * Bipolar I, II disorder * Schizophrenia, schizoaffective disorder, schizophreniform, delusional disorder, or current psychotic symptoms * Substance abuse in past 15 days * Substance dependence not weaned * Benzodiazepine and any anticonvulsant during rTMS treatment course * ECT failure in medical history * Contra-indication to rTMS and MRI * Pregnancy * Difficulty to obtain informed consent