Safety and Immunogenicity Study of a DNA Vaccine Combined With Protein Vaccine Against HIV/AIDS

Inclusion Criteria: 1. HIV-1 uninfected adults aged 18-45 years, as confirmed by a medical history, physical exam, and laboratory tests during screening 2. In 50% of study volunteers, positive for S. mansoni infection but negative for other helminth infections. 3. In 50% of study volunteers, negative for S. mansoni and other helminth infections 4. Willing to forgo treatment with praziquantel until after completion of week 26 visit in the trial. 5. Able and willing to provide written informed consent prior to screening 6. Aged 18 through 45 years on the day of first vaccination 7. Able and willing to complete screening (about 1 month) and available for the planned follow-up period (9months) 8. Willing to undergo HIV testing, risk reduction counselling, receive HIV test results and committed to maintaining low risk behaviour for the trial duration 9. If female of childbearing potential (not menopausal or sterilised), willing to use a non-barrier contraceptive method from screening through the end of the study. Acceptable contraceptive methods include hormonal contraceptives (injection, transdermal patch, or implant) and intrauterine device (IUD). 10. Willing to provide blood, urine and stool samples for laboratory examination Exclusion Criteria: 1. HIV-1 infection 2. Infection with other helminths 3. Symptomatic and asymptomatic malaria infection (presence of malaria parasites on thick blood smear) 4. Treatment with praziquantel in the past 3 months 5. S. mansoni egg count of\>2000 eggs per gram of stool 6. Clinically significant acute or chronic illness at the time of randomization. 7. Any clinically relevant abnormality on history or examination 8. Use of immunosuppressive medication (other than inhaled or topical immunosuppressants) 9. Receipt of immunoglobulin within past 60 days 10. Abnormal laboratory values as specified below from blood collected within 28 days prior to randomization: 1. Hematology * Haemoglobin \<9.0 g/dL or\<5.59 mmol/L * Absolute Neutrophil Count (ANC): \< 1000/mm3or \< 1.0 x 109/L * Absolute Lymphocyte Count (ALC): ≤ 500/mm3or ≤ 0.5 x 109/L * Platelets: ≤ 90,000 ≥ 550,000/mm3or ≤ 90 x 109 ≥ 550 x 109/L 2. Chemistry * Creatinine: \> 1. 1 x ULN * AST: \>2.6 x ULN * ALT: \>2.6 x ULN 3. Urinalysis: abnormal dipstick confirmed by microscopy * Protein 2+ or more * Blood 2+ or more (not due to menses) 11. Reported high-risk behaviour for HIV infection within 3 months prior to first vaccination, as defined by: * Unprotected sexual intercourse with a known HIV-infected person, a partner known to be at high risk of HIV infection or a casual partner * Unprotected sexual intercourse with more than one sexual partner * Engagement in sex work for money or drugs * Use of recreational drugs (e.g. marijuana) and/or weekly or more frequent alcohol use * Current or past STI 12. History or evidence of autoimmune disease. 13. Positive for Hepatitis B surface antigen (HbsAg), positive for antibodies to Hepatitis C virus (HCV) or active syphilis. 14. Receipt of blood or blood products within the previous 6 months 15. History of severe allergic reactions to any substance requiring hospitalization or emergency medical care (e.g. Steven-Johnson syndrome, bronchospasm or hypotension) 16. Prior or current participation in another investigational agent trial 17. Current anti-tuberculosis (TB) prophylaxis or therapy 18. If female, currently pregnant (positive serum or urine pregnancy test), planning to get pregnant in the next 9months or lactating 19. History or evidence of any systemic disease or any acute or chronic illness that, in the opinion of the investigator, may compromise the volunteer's safety or interfere with the evaluation of the safety or immunogenicity of the vaccine