Regional Activation of Leukocytes in Coronary Artery Disease

Sint Franciscus Gasthuis97 enrolled

Overview

This study aims to evaluate the role of leukocyte activation in coronary artery disease

1. The primary aim of REAL CAD is to determine regional differences of leukocyte activation in different vascular beds in vivo. 2. The secondary aim is to investigate differences in leukocyte activation between diabetic and CAD subjects and patients suffering from both. 3. The third aim is to investigate the relationship between complement components, triglycerides and leukocyte activation markers in order to gain more insight into the causative processes leading to activation of leukocytes. 4. The fourth aim is to get more insight in the MBL genotypes and serum levels of CAD and/or diabetic patients and the 'healthy' groups included in our study.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Inflammation Coronary Artery Disease

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Subjects scheduled to undergo a coronary catheterization * Provide written informed consent * Aged \>18 and \<75 years * BMI \< 35 kg/m2 Exclusion Criteria: * Emotionally and intellectually not capable to decide about participation in the study and the consequences of participation. Subjects who are not able to understand the patient information * CRP \> 20 mg/l * Unstable angina pectoris * CABG or PTCA during the last 6 months * Alcohol use \> 2 units/day * Aberrations in kidney, liver and thyroid function * Use of any experimental medication within 6 months of the catheterization * The use of immunosuppressive drugs

Locations (2)

Sint Franciscus Gasthuis

Rotterdam, South Holland, Netherlands

Sint Franciscus Gasthuis

Rotterdam, South Holland, Netherlands

Outcomes

Primary Outcomes

Assess the level of leukocyte activation in different vascular beds, by measuring monocyte CD11b and neutrophil CD11b and CD66b in blood obtained from the left and right coronary artery, the abdominal aorta, the femoral artery and a peripheral vein

Time frame: Baseline

Secondary Outcomes

Investigate differences in leukocyte activation between patients with and without diabetes mellitus or coronary artery disease by comparing the level of monocyte CD11b and neutrophil CD11b and CD66b

Time frame: Baseline

To investigate the predictive value of leukocyte activation markers CD11b and CD66b in different vascular regions in the prediction of future coronary events, by measuring these markers at baseline

Time frame: 6 years follow-up

Data from ClinicalTrials.gov

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