This is a retrospective study to evaluate the outcomes of endoscopic biliary drainage according to the timing of distal malignant biliary obstruction (MBO) in relation to gastric outlet obstruction (GOO) and the location of GOO.
This is a multinational multicenter retrospective cohort study to evaluate the outcomes of endoscopic biliary drainage in patients with a duodenal SEMS. Endoscopic ultrasound-guided biliary drainage (EUS-BD), including choledochoduodenostomy, hepaticogastrostomy, antegrade biliary stenting or a combination, and endoscopic retrograde cholangiopancreatography (ERCP) with stenting are to be compared. Specifically, the outcomes are to be evaluated according to the timing of distal MBO in relation to GOO and the location of GOO.
Study Type
OBSERVATIONAL
Enrollment
200
EUS-BD or ERCP
Eastern Hepatobiliary Hospital, Second Military Medical University
Shanghai, China
Time to recurrent biliary obstruction
Recurrent biliary obstruction is defined as a composite endpoint of either occlusion or migration of biliary stent, and time to recurrent biliary obstruction is time from biliary drainage to recurrence of biliary obstruction.
Time frame: Up to 1 year
Causes of recurrent biliary obstruction
Causes of recurrent biliary obstruction include sludge, food impaction, ingrowth, tumor overgrowth, hemobilia and others.
Time frame: Up to 1 year
Functional success rate of biliary drainage
Functional success is defined when bilirubin decreases \< 50% or is normalized within 2 weeks.
Time frame: 2 weeks
Procedure-related complication of biliary drainage and duodenal meta stent placement (type and severity)
Complications and their severity are determined using the American Society of Gastrointestinal Endoscopy guidelines.
Time frame: 30 days
Survival time
Survival time is defined as the period between biliary stent placement and death.
Time frame: Up to 2 year
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