The Role of Bifidobacterium Animalis Ssp Lactis DR10 Supplementation in Women During Pregnancy and Lactation on Breast Milk IL-8 and Gut Mucosa Integrity in Infant

Naomi Esthernita70 enrolled

Overview

Hopefully this research can help to provide the optimal nutrition management from pregnancy so that the babies wiil born with better quality of health and reduce the morbidity and mortality. Until now, there is no data regarding probiotics in Indonesien breastmilk and the role of probiotics supplementation on pregnant women to the baby especially from inflammation pathways. The investigators hope the result of this research can help reducing infant morbidity and mortality rate in Indonesia, also has a benefit for future research.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE

Enrollment

Conditions

Bifidobacterium

Interventions

Probiotic

Eligibility

Sex: FEMALEHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * pregnant women ,gestation age 32-34 weeks, normal pregnancy, plan to deliver spontaneously, no antibiotic * tend to give exclusive breastfeeding * want to join the research * well doing baby Exclusion Criteria: * pregnant women with pre-eclampsia,bleeding,infection,premature rupture of the membrane or other chronic disease * plan to deliver by caesarean section

Outcomes

Primary Outcomes

Gastrointestinal microbiota examination by DNA extraction and real time PCR

Time frame: 3 months

Examination of IL-8 in breast milk

Time frame: 3 months

Examination of urine IFABP

Time frame: 3 months

Calprotectin examination in stool of infants aged 3 months

Time frame: 3 months

Alpha 1 antitrypsin

Time frame: 3 months

The Role of Bifidobacterium Animalis Ssp Lactis DR10 Supplementation in Women During Pregnancy and Lactation on Breast Milk IL-8 and Gut Mucosa Integrity in Infant

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes