Hypothalamo-pituitary Adrenal Axis Activity and Neuropsychological Consequences in Type 1 Diabetes in Childhood

University Hospital, Bordeaux79 enrolled

Overview

The general objective is to precise the role of HPA axis activity in neuropsychological consequences of type 1 diabetes. The investigators hypothesize that hyperactivity of HPA axis is associated with higher scores of depression and changes in hippocampal volume and mean diffusion.

* Background: Type 1 diabetes could be associated with hyperactivity of hypothalamo-pituitary adrenal (HPA) axis. Type 1 diabetes is associated with higher frequency neuropsychological consequences as mood disorders and structural changes in brain, particularly in hippocampus. * Purpose: To describe the association between HPA axis activity and anxiety and depression scores in 6-12 year's old diabetes children. * Abstract: The general objective is to precise the role of HPA axis activity in neuropsychological consequences of type 1 diabetes. The investigators hypothesize that hyperactivity of HPA axis is associated with higher scores of depression and changes in hippocampal volume and mean diffusion.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Type 1 Diabetes

Interventions

T1DM analysesBIOLOGICAL

Eligibility

Sex: ALLMin age: 6 YearsMax age: 12 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Diabetic group: * diabetes for 1 year * 6-12 year's old * included in ISIS-DIAB protocol. * Control group: * brother or sister of a diabetic children * 6-12 year's old. Exclusion Criteria: * Per os or inhaled corticoid in the previous month of inclusion. * Acute infectious disease in the previous week of inclusion. * Other chronic disease than diabetes type1. * Psychiatric disorders or psychiatric treatment.

Locations (3)

Service d'endocrinologie pédiatrique CHG Bayonne Centre Hospitalier de la Côte Basque

Bayonne, Aquitaine, France

CHU de Bordeaux Hôpital Pellegrin

Bordeaux, Aquitaine, France

Service d'endocrinologie pédiatrique - Hôpital de la mère et de l'enfant - CHU de LIMOGES

Limoges, Limousin, France

Outcomes

Primary Outcomes

Mean of nocturnal urinary free cortisol during 5 days.

Time frame: During 5 days after the inclusion

Depression (CDI) score

Time frame: At the inclusion

Secondary Outcomes

Mean of awakening salivary cortisol and mean of nocturnal urinary cortisol metabolites during 5 days

Time frame: During 5 days after the inclusion

Profiles of glucocorticoid sensitive genes expressed in peripheral blood mononuclear cells.

Time frame: At the inclusion

Anxiety (STAI) score

Time frame: At the inclusion

Polymorphisms of genes involved in HPA axis activity

Time frame: At the inclusion

Hippocampal volume and mean diffusion

Time frame: At the inclusion

Data from ClinicalTrials.gov

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