In this study the aim is to compare the effect of the type of anaesthetic drug used during oocyte retrieval on fertilization rates of oocytes retrieved after ovarian stimulation for in-vitro fertilization.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
180
Propofol intravenous infusion for introduction and maintance of anaesthesia at doses 3-5mg depending on the total time needed for completion of oocyte retrieval
Patients will receive thiopental in addition to fentanyl for introduction and maintanance of anaesthesia at doses 7mg. IF required patients will receive a repeat dose of 1-3mg of thiopental depending on the totla time needed to complete oocyte retrieval
Unit for Human Reproduction, 1st Dept of OB/Gyn, Medical School, Aristotle UNiversity of Thessaloniki
Thessaloniki, Thessaloniki, Greece
Fertilization rate
The number of oocytes fertilized divided by the number of oocytes in which fertilization was attempted per randomized patient
Time frame: First 24h after oocyte retrieval
Number of MII oocytes
Time frame: 12h after oocyte rertieval
Pregnancy rate
Patients with positive (\>20 IU/L) b-hCG test at 14 days after embryo transfer
Time frame: 14 days after embryo transfer
Implantation rate
Number of gestational sacs per embryos transferred per patient
Time frame: 40 days after embryo traansfer
The concentration of propofol or thiopental in the follicular fluid of the dominant (larger) follicle aspirated at oocyte retrieval
Time frame: 12 hours after oocyte retrieval
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.