This study evaluates the difference in pregnancy rate transferring a healthy blastocyst in natural or artificial cycle.
The aim of the study was to verify the implantation capacity and ongoing pregnancy rate of vitrified warmed euploid blastocyst in natural cycle versus endometrial artificial cycle with gonadotropin-releasing hormone (GnRH-agonist) pituitary suppression.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
236
healthy blastocyst transfer in natural and hormonal cycle
European Hospital
Rome, RM, Italy
European Hospital
Rome, Roma, Italy
clinical pregnancy rate confirmed by ultrasound evidence of fetal heart activity
Time frame: 12 weeks after embryo transfer
live-birth rate confirmed by the number of born
Time frame: term pregnancy delivery
cost-benefit of two endometrial preparation protocol
Assessment of drug cost and the count of clinical visit, laboratory dosages and venous sampling
Time frame: 30 weeks beginning from day 21 of the previous cycle day up to the pregnancy test
The number of patients with the anxiety and depression increase
the psychological questionnaire (HADS) administered on four time point
Time frame: Six weeks beginning on the day of treatment start, on the day of progesterone administration, on the day of blastocyst transfer and the pregnancy test
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