Multimodal Monitoring of Radiotherapy Response in Squamous Cell Cancer

Inclusion Criteria: 1. Morphologically (pathology or cytology) verified, previously untreated squamous cell carcinoma (SCC) of the oral cavity, oropharynx, uterine cervix, oesophagus or lung. 2. The patient should be planned for treatment with radiotherapy alone or in combination with concomitant medical therapy 3. The tumour shall be radiologically and/or visually identifiable and accessible for biopsy without the need for general anaesthesia or other major interventions 4. The patient must be at least 18 years of age, able to understand the given information and, leave a written informed consent to participate Exclusion Criteria: 1. The patient is unwilling to participate in the study 2. Patients with adjuvant post-operative radiotherapy (i.e. no visible remaining tumour) 3. Pregnancy or lactation 4. Contraindications to investigations with MRI, gadolinium contrast or PET-tracers 5. Patients with an estimated glomerular filtration rate (GFR) \<60 ml/min/1.73m2. 6. Severe co-morbidities that are judged to significantly compromise survival in a two-years perspective.