In this phase 1 pilot study, positron emission tomography (PET/CT) imaging will be used to determine the biodistribution, metabolism and excretion of a novel radiotracer \[18F\]Fluortriopride (\[18F\]FTP).
\[18F\]FTP is a novel radioactive tracer that has shown potential in labeling dopamine D3 receptors through PET/CT imaging. This is a phase 1 study design meant to evaluate safety, biodistribution and brain uptake of \[18F\]FTP in healthy volunteers.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
29
All subjects will receive a \[18F\]Fluortriopride PET/CT scan
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
Determine biodistribution of the radioactive investigational drug ([18F]fluortriopride) in healthy volunteers and calculate human dosimetry.
Assessing the biodistribution of the radioactive investigational drug (\[18F\]fluortriopride) and calculation of human dosimetry in healthy volunteers are completed with MRI results from Dynamic Brain cohort, PET/CT results and laboratory results.
Time frame: 1 week
Demonstrate the feasibility of imaging the brain with the dopamine D3 receptor imaging agent [18F]fluortriopride
Participants will complete an anatomical MRI scan on an MRI scanner (without contrast) to enable precise anatomic location of the PET scan results. MRI and PET images will be co-registered so that the anatomical structures observed on the MRI can be accurately outlined on the PET scans for analysis.
Time frame: 1 week
Evaluate the safety of [18F]fluortriopride
Safety of the radioactive investigational drug (\[18F\]fluortriopride) as measured by the number of participants with adverse events and significant changes in laboratory and/or PET/CT results.
Time frame: 24 hours
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