Prophylaxis of Deep Vein Thrombosis Following Total Hip Arthroplasty

Inclusion Criteria: * Male or female without childbearing potential aged ≥20 years who were scheduled for elective primary THA Exclusion Criteria: * recent history of active bleeding or VTE * known genetic disorder associated with bleeding tendency or any condition related with an increased risk of bleeding * persistent blood pressure of ≥160mmHg systolic and/or ≥100 mmHg diastolic at baseline * myocardial infarction or cerebrovascular accident within three months of the scheduled surgery * major surgery in the prior three months * renal insufficiency with a creatinine clearance \<60mL/min , hepatic failure combined with coagulopathy, or thrombocytopenia (platelets \< 100,000/mm³), or planned indwelling epidural catheter for \> 6 hours after the end of surgery