Diet, Obesity and Cardiovascular Risk Study

Tufts University107 enrolled

Overview

Controversy exists about the role of dietary glycemic index (GI) and fat content and cardiovascular risk. Our aim was to assess the long term effects of altering dietary GI, carbohydrate, and fat on body weight, lipids, glucose homeostasis, and C reactive protein (CRP) in overweight and obese subjects. Men and post-menopausal women with body mass index values between 28-38 kg/m2 were placed on an isoweight average American diet for 5 weeks, then randomized to one of 4 diets which differed in GI, carbohydrate and fat content with calorie restriction for 12 weeks. The same diets were continued for 5 weeks under isoweight conditions, and in the free-living state for 48 weeks.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

TRIPLE

Enrollment

107

Conditions

Cardiovascular Diseases Obesity

Interventions

Eligibility

Sex: ALLMin age: 45 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI 28-28 kg/m2 * Male or postmenopausal female 45-65 yr Exclusion Criteria: * Abnormal thyroid, liver, kidney function * Abnormal hemoglobin * LDL-cholesterol ≤ 100 mg/dL * Fasting triglycerides ≥ 400 mg/dL * Diabetes or on medication for diabetes * Chronic illness * Elevated blood lipids

Outcomes

Primary Outcomes

Change in body weight

Time frame: Baseline to 12 weeks