Innovation in Endobronchial Sampling

KU Leuven20 enrolled

Overview

Evaluating an integrated diagnostic work-up of virtual navigation bronchoscopy (VNB), confocal laser endomicroscopy and micro computerized tomography (micro-CT) in the diagnostic path of pulmonary lesions in the non-oncological patient.

The region(s) of interest that has/have to be sampled, will be selected upfront. Guided by the endobronchial pathway that is created by virtual bronchoscopy, the flexible bronchoscope will be navigated to the regions of interest and an optical biopsy of the region will be obtained using pCLE. One biopsy sample will be processed in the endoscopy suite to be able to prepare it for micro-CT analysis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Diffuse Interstitial Lung Disease

Interventions

Advanced endoscopic imaging modalitiesPROCEDURE

Virtual bronchoscopic navigation, confocal laser endomicroscopy, micro CT

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Presence of diffuse pulmonary disease necessitating bronchoscopic evaluation. * Informed consent available * Age \> 18 * FVC \> 50%pred * DLCO \> 35%pred * PaO2 \> 55 mmHg, pCO2 \< 45 mmHg (ambient air) * No exclusion criteria Exclusion Criteria: * Age \> 75 * Systolic arterial pressure in the pulmonary artery : PAPS \>40mmHg * Platelet count \<100000/µl * INR \> 1.4 * BMI \>30 * Diffuse bullous lung disease * Active anti-platelet or anticoagulant treatment * Active heart failure or unstable coronary heart disease

Locations (1)

UZ Leuven

Leuven, Belgium

RECRUITING

Outcomes

Primary Outcomes

Diagnostic yield

Time frame: postprocedural

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.