Myocardial Dysfunction at Early Phase of Traumatic Brain Injury : Evaluation by Two Dimensional and Speckle Tracking Transthoracic Echocardiography

University Hospital, Grenoble40 enrolled

Overview

Traumatic brain injury (TBI) is a frequent pathology leading to major morbidity and mortality in young people. Cerebral flood flow maintenance is a major goal directed therapy to improve the prognosis of the patient. Due to cerebral-myocardial interaction, a myocardial dysfunction might occur at the early phase of the traumatic brain injury. This myocardial dysfunction could be partly responsible for a decrease in cerebral blood flow. In such case, improving myocardial dysfunction may help to increase cerebral blood flow and improve patient prognosis. In clinical practice the easiest and non invasive way to explore myocardial dysfunction is with transthoracic echocardiography. The objective of this trial is to investigate myocardial dysfunction at the early phase of traumatic brain injury, compared with a controlled group without TBI.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Enrollment

Conditions

Traumatic Brain Injury

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

TBI patients Inclusion Criteria: * Isolated and non opened traumatic brain injury * 18 - 65 years old * Intubated and mechanically ventilated * Glasgow score \< or = 9 or * Glasgow score between 9 and 13 (included) and Following Traumatic Coma Data Bank Tomographic Damages diffuse injuries type III or IV or mass lesion over 25ml and/or neurosurgical injuries * Medical insurance Exclusion Criteria: * Treated major cardiovascular risks factors * cardiovascular past medical history (acute cardiovascular event) * Cardio thoracic surgery * Brain dead status * Inotrope drugs * Severe polytraumatism * Acute haemorrhage * Non echogenic patient * High level athlete * Incapacitated person by law and pregnant women * Discovery during echocardiography of underlying cardiomyopathy * Urgent neurosurgery required Control patients Inclusion Criteria: * Isolated and non opened traumatic brain injury * 18 - 65 years old * Intubated and mechanically ventilated * Paired with TBI patient on age, BMI and sex * Undergoing urgent non severe surgery * Medical insurance Exclusion Criteria: * Traumatic brain injury * Treated major cardiovascular risks factors * cardiovascular past medical history (acute cardiovascular event) * Cardio thoracic surgery * Inotrope and vasopressive drugs * Circulatory failure * Non echogenic patient * High level athlete * Incapacitated person by law and pregnant women * Discovery during echocardiography of underlying cardiomyopathy * Urgent neurosurgery required