The purpose of this study is to determine the effectiveness of recommending either a Paleolithic based diet or the United States Department of Agriculture MyPlate guidelines with or without exercise on physical conditioning, hormones related to energy metabolism, body composition, resting energy expenditure, blood biomarkers, and urine in young, adult females.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
NONE
Enrollment
20
To consume a weight maintenance diet based on the United States Department of Agriculture MyPlate nutrition recommendations for eight weeks.
To consume a weight maintenance diet based on the United States Department of Agriculture MyPlate nutrition recommendations and aerobic and resistance training four days per week for eight weeks.
To consume a weight maintenance diet based on alternative (Paleolithic based) nutrition recommendations for eight weeks.
Clemson University
Clemson, South Carolina, United States
Change in aerobic conditioning
Peak oxygen consumption
Time frame: Baseline and 8 weeks
Change in anaerobic power
Wingate anaerobic threshold
Time frame: Baseline and 8 weeks
Change in strength
Chest press and leg press estimated one repetition maximum
Time frame: Baseline and 8 weeks
Change in resting energy expenditure
24 hour kcal and respiratory quotient
Time frame: Baseline and 8 weeks
Change in urine
Osmolality
Time frame: Baseline and 8 weeks
Change in insulin (plasma)
Radioimmunoprecipitation assay
Time frame: Baseline and 8 weeks
Change in glucagon (plasma)
Radioimmunoprecipitation assay
Time frame: Baseline and 8 weeks
Change in ghrelin (plasma)
Total and active ghrelin; Radioimmunoprecipitation assay
Time frame: Baseline and 8 weeks
Change in peptide YY 3-36 (plasma)
Radioimmunoprecipitation assay
Time frame: Baseline and 8 weeks
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To consume a weight maintenance diet based on alternative (Paleolithic based) nutrition recommendations and aerobic and resistance training four days per week for eight weeks.
Change in adiponectin (plasma)
Radioimmunoprecipitation assay
Time frame: Baseline and 8 weeks
Change in leptin (plasma)
Radioimmunoprecipitation assay
Time frame: Baseline and 8 weeks
Change in tumor necrosis factor alpha (plasma)
ELISA
Time frame: Baseline and 8 weeks
Change in interleukin 6 (plasma)
ELISA
Time frame: Baseline and 8 weeks
Change in undercarboxylated osteocalcin (plasma)
enzymeimmunoassay
Time frame: Baseline and 8 weeks
Change in total cholesterol (plasma)
Colorimetric enzyme assay
Time frame: Baseline and 8 weeks
Change in HDL cholesterol (plasma)
Colorimetric enzyme assay
Time frame: Baseline and 8 weeks
Change in non-HDL cholesterol (plasma)
Calculated from triacylglycerol, total cholesterol and HDL cholesterol
Time frame: Baseline and 8 weeks
Change in triacylglycerol (plasma)
Colorimetric enzyme assay
Time frame: Baseline and 8 weeks
Change in non-esterified fatty acids (plasma)
Colorimetric enzyme assay
Time frame: Baseline and weeks
Change in glucose (plasma)
Colorimetric enzyme assay
Time frame: Baseline and 8 weeks
Change in ketones (plasma)
Colorimetric enzyme assay
Time frame: Baseline and 8 weeks
Change in fat mass
Dual energy x-ray absorptiometry
Time frame: Baseline and 8 weeks
Change in fat free mass
Dual energy x-ray absorptiometry
Time frame: Baseline and 8 weeks
Change in bone mass
Dual energy x-ray absorptiometry
Time frame: Baseline and 8 weeks