Nebulized Beclomethasone Dipropionate Improves Respiratory Lung Function in Preschool Children With Recurrent Wheezing

Inclusion Criteria: * Informed and subscribed consent before any procedure * Age range : 2 - ≤5 years * Male and female patients * Recurrent wheezing affected ( ≥ 4 episodes in the last 12 months) * PAI positive (at least one primary and two secondary ): Primary: 1. one parent with asthma 2. Atopic Dermatitis 3. sensibilisation to air allergen Secondary: 1. Food sensibilization 2. wheezing also not during the infective episodes 3. eosinophilia (\>4%) Exclusion Criteria: * story of severe wheeze requiring hospitalization * treatment with inhaled glucocorticoids during the previous 4 weeks or with oral glucocorticoids in the previous 8 weeks * structural abnormalities of the lungs (tracheobronchial bronchomalacia, external compressions, etc) * Persistent infections * aspiration lung disease (gastroesophageal reflux disease, etc.) * Cystic fibrosis * prematurity or bronchopulmonary dysplasia * Tuberculosis * primary ciliary dyskinesia * congenital heart disease * pulmonary foreign body * bronchiectasis * Immunodeficit