Impairment of Central Coherence in Restrictive Anorexia Nervosa (CoCA)

Nantes University Hospital122 enrolled

Overview

The current etiological pathological model of anorexia nervosa is poly-factorial involving individual genetic and psychological factors, in close interaction with environmental, family and socio-cultural factors. Among these factors, this study focuses on the central coherence process (cognitive ability to integrate complex information into a comprehensive meaning), in the active phase of the disease. Therefore, patients followed in the addiction service of the Nantes University Hospital will perform neuropsychological tests assessing executive functions involved in the process of central coherence. Impairment of central coherence process could act as a maintenance factor of the disease, particularly in connection with body dysmorphic disorder. The therapeutic perspectives acting on the central coherence process like cognitive remediation deserve to deepen knowledge on the cognitive profile of patients with anorexia nervosa.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

122

Conditions

Anorexia Nervosa

Interventions

The content of the assessment will be the same for all subjects and will consist of a part of cognitive assessment (National Reading Test, Rey Osterreich Complex Figure, Hayling Sentence Completion Task, verbal memory, digit sequencing, token motor task, verbal fluencies, symbol coding, tower of London) and self-assessment (Mini International Neuropsychiatric Interview, Beck Depression Inventory, State Trait Anxiety Inventory, Wender Utah Rating Scale, Adult Self-Report Scale Symptom Checklist, UPPS Impulsive Behavior Scale)

Eligibility

Sex: FEMALEMin age: 15 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * For the patients : * Woman. * Aged of more than 15 years and 3 months. * Followed in the addiction service of the University Hospital of Nantes (consultations and / or hospitalizations) for Restrictive Anorexia Nervosa (according to the diagnostic criteria of DSM-IV-TR). * French language mastered. * Having signed the consent if major and if not the legal representatives have signed the consent (for minors). * For the volunteers : * Women. * Aged of more than 15 years and 3 months. * French language mastered. * Having signed the consent if major and if not the legal representatives have signed the consent (for minors). Exclusion Criteria: * For the patients : * Man * Age under 15 years and 3 months old * Current Renutrition by nasogastric tube * Personal history of: * Head injury, neurodegenerative diseases, epilepsy unbalanced, unbalanced endocrine disorder, mental retardation * Support for current or past cognitive remediation * Opposition of the patient and / or his legal representatives if minor * Subject under legal guardianship * Current participation or in the past to pharmacological research protocol (time since the end of their participation in the protocol less than one year) * French language not mastered * For the volunteers : * Man * Age under 15 years and 3 months old * Current Renutrition by nasogastric tube * Personal history of: * Eating disorders * Head injury, neurodegenerative diseases, epilepsy unbalanced, unbalanced endocrine disorder, mental retardation * Support for current or past cognitive remediation * Opposition of the volunteer and / or his legal representatives if minor * Subject under legal guardianship * Current participation or in the past to pharmacological research protocol (time since the end of their participation in the protocol less than one year) * French language not mastered

Outcomes

Primary Outcomes

Percentages for types I and III of the copy of the figure of Rey

Time frame: 90 minutes

Secondary Outcomes

Average scores for all cognitive and psychiatric tests

Time frame: 90 minutes

Measure of relationships between average scores for all cognitive and psychiatric tests and socio-demographic and clinical data

Time frame: 90 minutes

Impairment of Central Coherence in Restrictive Anorexia Nervosa (CoCA)

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes