Nonalcoholic Fatty Liver Disease and Atherosclerotic Risk in Children

Augusta University175 enrolled

Overview

Nonalcoholic fatty liver disease is a serious health condition in overweight children which can lead to heart disease. This project will examine the links between liver health and cardiovascular risk factors in overweight and obese children, and will test the effect of a long-term after-school exercise program. Provision of comprehensive evidence for the benefits of exercise on children's health may reduce barriers to vigorous physical activity programs during a childhood obesity epidemic.

This is an ancillary study adding cardiometabolic outcome measures to an ongoing NIH-funded randomized trial of exercise in overweight children ("SMART study," R01 HL087923, P.I. Davis, NCT02227095). This presents the opportunity to obtain detailed measures of liver and vascular health to provide information about the effects of exercise on these conditions.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

175

Conditions

Overweight and Obesity Non-alcoholic Fatty Liver Disease

Interventions

ExerciseBEHAVIORAL

Heart rate monitors worn by each child at each session

After-school programBEHAVIORAL

Supervised recreational program with token economy

Eligibility

Sex: ALLMin age: 8 YearsMax age: 11 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 8-11 years of age * Overweight or obese (BMI-for-age \>= 85th percentile) * Able to participate in exercise testing and intervention * Participating in the SMART Study Exclusion Criteria: * Medical condition or medications that would interfere with measurements * Participation in weight control or formal exercise program outside physical education that meets more than 1 day/week * T-score \> 75 on the BRIEF Behavior Regulation scale to avoid program disruption * Unable to complete magnetic resonance imaging.

Locations (1)

Georgia Prevention Institute

Augusta, Georgia, United States