Genetic Predictors of Responsiveness to Radiofrequency Denervation in Chronic Low Back Pain

Inclusion Criteria: * Diagnosed with chronic low back pain which is unresponsive to conservative treatment (including suitable analgesics and physical therapy); * Willing to provide consent * Subject is capable of comprehending the patient information sheet and has the capacity to give their informed consent to all study procedures in English * Be 18 years or older at the time of enrolment; * Have specific low back pain that is aggravated by hyperextension and rotation of the spine, with or without hip, buttock or leg pain that does not follow a known dermatomal distribution * Paraspinal Tenderness * A "positive" response to a uni/bi-lateral MBB\* (a response is considered positive when a subject experiences at least 50% reduction in pain scores after the block, regardless of the duration of pain relief) Exclusion Criteria: * Patients who had had any previous back surgery * Patients who had previous RF treatments for facet joints mediated pain * Patients with another significant cause of low back pain (like spinal stenosis, disc herniation, spondylolisthesis, malignancy, infection or trauma); * Radicular pain (pain with neuropathic characteristics following one or more nerve root distribution) * Patients with bleeding complications or coagulopathy issues; * Concurrent participation in other experimental trials; * Known history of adverse reactions to local anesthetics; * Pregnant or lactating women; * Refusal to provide informed consent for blood banking * Any other complication which in the view of the investigator may interfere with the study procedures or the measurement of the accurate study outcomes