Master Allergen Child Nutrition. Reintroduction of Small Doses

University Hospital, Angers400 enrolled

Overview

Reintroduction of small doses of food in allergic children to lightening the elimination diet.

In four groups of allergic children (peanuts, wheat , milk and egg), a reintroduction of 4 small increasing doses of allergen is carried out progressively double-blind placebo- cons , randomized, during a hospitalization. The procedure for reintroduction of small doses (MPD) is stopped at the appearance of intolerance (in taking a dose of allergen or placebo) defined by the onset of allergic symptoms or objective severe abdominal pain within 45 minutes of taking.

Study Type

INTERVENTIONAL

Allocation

Masking

NONE

Enrollment

400

Conditions

Food Allergies

Interventions

allegic foodOTHER

Reintroduction procedure for small doses : * Administration of the first dose * Clinical monitoring for 45 minutes * Administration of the second dose

PlaceboOTHER

Eligibility

Sex: ALLMin age: 9 MonthsMax age: 16 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Allergic children 1 and 16 years for peanut, egg and wheat. So, for milk between 9 months and 16 years. * Accurate diagnostic * Allergic react rapidly and acute Exclusion Criteria: * severe disease

Locations (1)

Denise Jolivot

Angers, Pays de Loire, France

RECRUITING

Outcomes

Primary Outcomes

Tolerance for each ingested dose is assessed by a clinical score

Tolerance is defined by the absence of allergy symptoms within 45 minutes of ingestion of the allergen dose in the absence of intolerance to previous placebo

Time frame: 45 minutes

Central Contacts

Martine Drouet

CONTACT

madrouet@chu-angers.fr

Data from ClinicalTrials.gov

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