Patients with advanced glaucoma that are candidates for trabeculectomy will be included. Thorough ophthalmic examination including best corrected visual acuity, slit lamp examination, intraocular pressure (IOP) measurement, gonioscopy, funduscopy and specularly microscopy will be performed for all participants. Patients will be assigned randomly to 2 groups. In one group they will undergo fornix based trabeculectomy with conventional MMC 0.02% soaked sponges application. In the other group 0.1 cc of 0.01 MMC will be injected into the tenon at the beginning of the surgery. The rest of the operation is the same for both groups as standard trabeculectomy. Ophthalmic examination including IOP measurement will be performed at one, 3 and 6th month post surgery. Specular microscopy will be requested at final follow up visit. Bleb morphology will be scored according to Indian grading system at 3rd and 6th months post surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
126
using 0.02 MMC soaked sponged under the conjunctiva for 1 to 3 minutes
0.1 cc of 0.01% MMC is injected into the tenon.
Unnamed facility
Tehran, Iran
RECRUITINGIOP (intraocular pressure)
Goldmann applanation tonometry
Time frame: until 6 months
Bleb morphology
scoring the bleb morphologic features according to Indian Grading System
Time frame: until 6 months
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