PERFECT Project - Part 1 - Study 3

University of Manitoba30 enrolled

Overview

The objectives are to test the acute effects of different bagels containing pulse ingredients on: 1) post-prandial blood glucose, insulin and appetite for two hours, and 2) food intake two hours following consumption of pulse products. The investigators hypothesize that bagels containing pulse ingredients will lead to lower blood glucose, insulin, appetite and food intake responses compared to non-pulse bagels.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Diabetes Prevention Obesity Prevention

Interventions

ControlOTHER

Non pulse ingredient bagel

Pea flourOTHER

Pulse ingredient bagel

Pea fibreOTHER

Pulse ingredient bagel

Pea protein

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Normoglycemic (\<5.6 mmol/L) and normotensive (systolic blood pressure \<140 mm Hg and diastolic blood pressure below \< 90 mm Hg) * BMI of 18.5-29.9 kg/m2 Exclusion Criteria: * Restrained eaters * Regularly skip breakfast * Smokers * Those who are active (organized activities or athletic training at a high intensity; ≥ 150 min per week of moderate to vigorous physical activity) * Those on medications that may influence study outcomes or have experienced any gastrointestinal related health conditions/surgeries over the past year. * Those unable to walk for an hour continuously

Locations (1)

Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba

Winnipeg, Manitoba, Canada

Outcomes

Primary Outcomes

Plasma Glucose and Insulin Concentrations

Measured in blood using intravenous catheter at 12 time points used to calculate area under curve (AUC). Glucose will be determined by automated methods using Abbot Spectrum CCX Analyzer, and Insulin will be measured by commercially available RIA kits

Time frame: 0-200

Food Intake

Ad-libitum meal. Food consumed measured by weight

Time frame: at 120 min

Subjective Appetite

Motivation-to-eat VAS questionnaire used to calculate area under curve (AUC)

Time frame: 0-200 min

Secondary Outcomes

Palatability of meal

Measured by VAS questionnaire

Time frame: at 140 mins

Palatability of treatments

Measured by VAS questionnaire

Time frame: at 5 mins

Physical comfort

Measured by VAS questionnaire at 12 time points used to calculate area under curve (AUC)

Time frame: 0 - 200 min

Energy/fatigue measured by VAS questionnaire

Measured by VAS questionnaire at 12 time points, used to calculate area under curve (AUC)

Time frame: 0 - 200 mins

Data from ClinicalTrials.gov

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