This study will compare genomic alterations between the parents and the patients with high-grade glioma.
Genomic changes leading to the formation of brain tumors are slowly being discovered. Despite advances in genomic technology, much analysis is hindered by the lack of control samples that could better delineate genomic alterations leading to disease. The ideal genomic control would be the genetic material of the parents of afflicted individuals. The researchers propose to then compare the genomic material from parents of siblings, both of whom have a diagnosis of a high-grade glioma. Additionally, the researchers will then compare the genomic alterations between the parents and the patients. This analysis will provide an unprecedented insight into genomic level changes that take place between parents and patients that resulted in the formation of a high-grade glioma.
Study Type
OBSERVATIONAL
Enrollment
4
Single saliva or blood sample measuring 10mL for genomic analysis.
Barrow Neurological Institute at St. Joseph's Hospital Medical Center
Phoenix, Arizona, United States
Total genomic sequencing
Researchers will perform total genomic sequencing using next generation sequencing technology to identify common variants associated with familial brain tumors. Upon sequencing of the genomic material, the data analysis will be done using standard statistical methods. We will use bioinformatics tools (high throughput sequencing of genome) to identify genomic changes between parents and patients.
Time frame: within 30 days of blood or saliva collection
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