Effects of Total Knee Replacement on Early Postoperative Cognitive Function in Elderly Patients

General Hospital of Ningxia Medical University100 enrolled

Overview

To investigate the effects of total knee replacement is harmful to Postoperative cognitive dysfunction

Postoperative cognitive dysfunction (POCD) is reported to occur after major surgery in elderly patients. They may especially experience problems in the weeks and months after surgery. Recent studies vary greatly in methods of evaluation and diagnosis of POCD, and the pathogenic mechanisms are still unclear. The investigators evaluated a large uniform cohort of elderly patients in a standardized approach after total knee replacement.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Perioperative Complications

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * aged ≥65 years; * ASA I or Ⅱ; * total knee replacement Exclusion Criteria: * Mini Mental State Examination \[MMSE\] score too low. * Parkinson or other neurological disease causing functional impairment. * Patients with a history of alcohol abuse (≥35 U per week) or daily use of anxiolytics were also excluded, as well as those with severe hearing or visual impairment.

Outcomes

Primary Outcomes

Effects of operation on early postoperative cognitive function in elderly patients

Time frame: up to 7days postoperatively

Secondary Outcomes

Postoperative cognitive dysfunction (POCD) was defined by Mini-Mental State Examination (MMSE) score

Time frame: up to 7days postoperatively

Data from ClinicalTrials.gov

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