Bioavailability Study of Oral OZ439 Prototype Granule Formulations Administered With Piperaquine Phosphate (PQP) Tablets

Inclusion Criteria: * Healthy males, or healthy females of non-childbearing potential ie surgically sterilised or post-menopausal * Body mass index of 18.0 to 30.0 kg/m2 inclusive. Total body weight \>50 kg at screening. * Must agree to use an adequate method of contraception. * Normal laboratory tests as judged by the Investigator. * Must have QTcF ≤450 ms, QTcB ≤450 ms for male subjects, QTcF ≤470 ms, QTcB ≤470 ms for female subjects and PR interval ≤200 ms for screening and pre-dose ECG measurements. Exclusion Criteria: * Male subjects who have currently pregnant partners or who have partners planning to be pregnant. * Evidence or history of clinically significant disease, or current infection.3. * Clinically relevant abnormalities in the ECG. * Family history of sudden death or of congenital prolongation of the QTc interval or known congenital prolongation of the QTc interval or any clinical condition known to prolong the QTc interval. * History of symptomatic cardiac arrhythmias or with clinically relevant bradycardia, heart rate ≤39 bpm. * Electrolyte disturbances, particularly hypokalaemia, hypocalcaemia or hypomagnesaemia. * History of any drug or alcohol abuse in the past 2 years prior to screening. * Receipt of an investigational drug or participation in another clinical research study within 90 days prior to drug administration. * Use of any prescription or non-prescription medications, vitamins, herbal supplements or dietary supplements, including protein supplements, within 14 days prior to the first dose of study drug. * Positive hepatitis B surface antigen, hepatitis C virus antibody or human immunodeficiency virus results. * Clinically significant abnormal biochemistry, haematology or urinalysis. * Positive urine drug screen result. * History of intolerance or hypersensitivity to PQP or any 4-aminoquinoline, or ascertained or presumptive hypersensitivity to the active principle and/or formulation ingredients; history of anaphylaxis to drugs or allergic reactions in general, that the investigator considers may affect the outcome of the study. * Presence or history of allergy requiring treatment; hayfever is allowed unless it is active. * Donation or loss of \>400 mL of blood within 90 days prior to drug administration.