A randomized, open-label, multiple-dose, crossover study to investigate the pharmacokinetic drug interaction between rosuvastatin and telmisartan/amlodipine in healthy male volunteers
A randomized, open-label, 2-treatment, 2-sequence, 2-period, multiple-dose, crossover design
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
41
Rosuvastatin and Telmisartan/Amlodipine: Rosuvastatin once daily for 9 days
Rosuvastatin and Telmisartan/Amlodipine: Telmisartan/Amlodipine once daily for 9 days
Rosuvastatin and Telmisartan/Amlodipine: Rosuvastatin and Telmisartan/Amlodipine once daily for 9days
Yonsei University Health System
Seoul, Seodaemun-gu, South Korea
AUCτ,ss , Cmax, ss of Rosuvastatin and Telmisartan, Amlodipine
Time frame: 72hours, 144hours
AUClast,ss of Rosuvastatin
Time frame: 72hours
AUCinf,ss of Rosuvastatin
Time frame: 72hours
Tmax,ss of Rosuvastatin
Time frame: 72hours
t1/2 of Rosuvastatin
Time frame: 72hours
AUClast,ss of Telmisartan, Amlodipine
Time frame: 144hours
AUCinf,ss of Telmisartan, Amlodipine
Time frame: 144hours
Tmax,ss of Telmisartan, Amlodipine
Time frame: 144hours
t1/2 of Telmisartan, Amlodipine
Time frame: 144hours
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