CSCC_ASC Therapy in Patients With Severe Heart Failure

Inclusion Criteria: 1. 30 to 80 years of age 2. Signed informed consent 3. Chronic stable IHD 4. HF (NYHA II-III) 5. LVEF ≤45% 6. Maximal tolerable angina and heart failure medication 7. Medication unchanged two months prior to inclusion 8. Angiography within six months of inclusion 9. No option for percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) 10. Patients who have had PCI or CABG within six months of inclusion must have a new angiography less than one month before inclusion or at least four months after the intervention to rule out early restenosis 11. Patients cannot be included until six months after implantation of a cardiac resynchronisation therapy device Exclusion Criteria: 1. Heart Failure (NYHA I or IV) 2. Acute coronary syndrome with elevation of CKMB or troponins, stroke or transitory cerebral ischemia within six weeks of inclusion 3. Other revascularisation treatment within four months of treatment 4. Moderate to severe valvular disease or valvular disease with option for valvular surgery 5. Diminished functional capacity for other reasons such as: coronary obstructive pulmonary disease (COPD) with forced expiratory volume (FEV) \<1 L/min, moderate to severe claudication or morbid obesity 6. Clinical significant anaemia, leukopenia, leukocytosis or thrombocytopenia 7. Clinically significant abnormal prothrombin or partial thromboplastin time or anticoagulation treatment that cannot be paused during cell injections 8. Patients with reduced immune response or treated with immunosuppressive medication 9. History with malignant disease within five years of inclusion or suspected malignity - except treated skin cancer other than melanoma 10. Pregnant women 11. Other experimental treatment within four weeks of baseline tests 12. Participation in another intervention trial