Cefotaxime Resistance in Treatment of Spontaneous Bacterial Peritonitis

Dr Ahmed Ali Elbaz254 enrolled

Overview

Spontaneous bacterial peritonitis (SBP) is a serious complication in cirrhotic patients, and the changes in the microbiological characteristics reported in the last years are impacting the choice of antibiotic used in the treatment. Cefotaxime has been the most extensively studied antibiotic for this infection. It is considered to be one of the first choice antibiotics because of low toxicity and excellent efficacy. Treatment of SBP by intravenous cefotaxime should be administered for a minimum 5 days. Antibiotic-resistant microorganisms have been increasingly reported especially to cefotaxime and its effect on the clinical outcome in treating SBP.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

254

Conditions

Spontaneous Bacterial Peritonitis

Interventions

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * patients with liver cirrhosis and ascites and clinical findings suspicious of ascitic fluid infection Exclusion Criteria: * Patients were excluded if they received antibiotics ten days prior to the hospital admission or there is evidence of secondary bacterial peritonitis, tuberculous peritonitis, malignant ascites or ascites due to other causes e.g. cardiac or renal diseases

Cefotaxime Resistance in Treatment of Spontaneous Bacterial Peritonitis

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes