Recently, positron emission tomography(PET) using 18F-Sodium fluoride (NaF) showed promising results for detecting vulnerable plaques in some pilot studies. In this study, the investigators will evaluate the diagnostic accuracy of 18F-NaF PET for non-invasively detecting vulnerable plaque, diagnosed by optical coherence tomography (OCT).
It has been well known that mechanism of acute coronary syndrome is plaque rupture and occlusion of coronary artery by this plaque rupture. Until now, evaluation of vulnerable plaque have been mainly performed with invasive imaging modalities such as optical coherence tomography or intravascular ultrasound. Recently, positron emission tomography(PET) using 18F-Sodium fluoride (NaF) showed promising results for detecting vulnerable plaques in some pilot studies. In this study, we will evaluate the diagnostic accuracy of 18F-NaF PET for non-invasively detecting vulnerable plaque, diagnosed by optical coherence tomography (OCT).
Study Type
OBSERVATIONAL
Enrollment
96
Seoul National University Hospital
Seoul, South Korea
RECRUITINGDifference of tissue background ratio measured by 18F-NaF PET between Vulnerable and non-vulnerable plaque
Difference of tissue background ratio measured by 18F-NaF PET between Vulnerable and non-vulnerable plaque
Time frame: up to 1 week
Differencce of Maximum SUV value between Vulnerable and non-vulnerable plaque
Tissue-to-background ratios were calculated for each participant by dividing the maximal SUV measured in aortic valves by the mean SUV of blood in inferior vena cava
Time frame: up to 1 week
Number of participants demonstrating at least 1 low-attenuation coronary atherosclerotic plaque
Number of participants demonstrating at least 1 low-attenuation coronary atherosclerotic plaque
Time frame: up to 1 week
Cardiac death and all-cause mortality
Between High-TBR and Low-TBR Plaque
Time frame: 1 year
Non-fatal target vessel myocardial infarction
Between High-TBR and Low-TBR Plaque
Time frame: 1 year
Target vessel revascularization
Between High-TBR and Low-TBR Plaque
Time frame: 1 year
Target vessel restenosis
Between High-TBR and Low-TBR Plaque
Time frame: 1 year
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