The purpose of this study is to examine healing after rotator cuff repair in subjects either treated with Doxycycline or placebo post-operatively.
Basic Science small animal model data indicates that matrix metalloproteinase (MMP) inhibition via doxycycline results in improved early rotator cuff repair biomechanics and histology. Rotator cuff repair failure and retear is a significant clinical problem. The effects of MMP inhibition on human rotator cuff tear repair healing and outcomes is unknown, but may potentially improve healing rates and outcomes. Our purpose is to evaluate the effects of early oral doxycycline on healing and outcomes following arthroscopic rotator cuff repair.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
antibiotic used to treat infection
placebo with no pharmacologic effect
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States
rotator cuff ultrasound of post-operative shoulder
An ultrasound of the post-operative rotator cuff to assess level of healing or defect present.
Time frame: one year
American Shoulder and Elbow Surgeons score
The survey is a standardized assessment of shoulder pain and function from the patient's perspective.
Time frame: 6 weeks, 3mos, 6mos, 1yr and 2 yr.
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