Ten patients will undergo uterine transplantation.
Ten patients that will be appropriately selected using a variety of physical and psychological assessments. The selected patients will undergo egg retrieval and subsequent freezing of embryos to enable IVF treatment following transplantation. Following uterine transplantation, using deceased donor allografts, the patients will be closely monitored for 12 months clinically, radiologically and immunologically until embryo transfer. Following successful embryo transfer the patients will continue to be monitored antenatally until they are delivered by Caesarean section.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
10
10 Patients will undergo oocyte retrieval and freezing
Appropriately matched uterine transplant allografts will be excised from deceased donors
Following egg freezing the patients will undergo uterine transplant from deceased donors
Transplant success
Efficacy as measured by successful graft transplantation with no clinical, immunological or radiological signs of graft rejection within the first 12 months post-operatively.
Time frame: 12 months
Pregnancy rate
Efficacy as measured by the number of patients successful of conception by IVF
Time frame: 24 months
Live birth rate
Efficacy as measured by the number of live births following successful conception
Time frame: 36 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Patients will be appropriately immunosuppressed, whilst being closely monitored clinically, radiologically and immunologically.
12 months after successful transplantation,the patients will undergo IVF
Following successful conception and antenatal period, the babies will be born by Caesarean Section