Roles of T Helper 1 Cytokines in Type 1 Diabetes

Istanbul Medeniyet University128 enrolled

Overview

The mechanism of β cell destruction in Type 1 diabetes is not exactly known, Our hyphotesis is that interferon gamma, interleukin-2 and tumor necrotizan factor alpha have impotant roles in β cell destruction.

T helper (h)1 cells are known to have important roles in the destruction or/and dedifferentiation of β-cells in type 1 diabetes (T1D). Significant increase in IFN-γ-producing Th1 cells in the pancreas and in the serum levels were determined in type 1 diabetic patients at diabetes oneset. This data indicated that this proinflammatory mediator serve as a biomarker of advanced autoimmunity. We aimed to investigate the relationship between Th1 cytokines (IFN-γ, IL-2 and TNF-α) and T1D and the effect of those cytokines on β-cell function.

Study Type

OBSERVATIONAL

Enrollment

128

Conditions

Type 1 Diabetes

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients giving consent to participate the study * Patients with type 1 diabetes according to WHO definiton Exclusion Criteria: * Acute and chronic inflammatory diseases, * significant concomitant diseases which may interfere with glucose metabolism * cancers, * hemoglobinopathies, * recently received antibiotics, * drugs influencing β-cell function and * insulin sensitivity or anti-inflammatory drugs * recent history of trauma

Locations (1)

Medeniyet University Goztepe Training and Research Hospital

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Roles of interferon gamma, interleukin-2, tumor necrotizan factor alpha in the pathogenesis of type 1 diabetes

Time frame: 3 day

Data from ClinicalTrials.gov

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